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Heartworm Comparison
Confused about Heartworm prevention options? These two charts compare current heartworm preventive products side by side to assist you in determining which is right for your situation.
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For Dogs or Cats
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Heartworm Preventing Ingredient
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Other Ingredients for Control of Other Parasites
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Other Parasites Controlled
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Mode of Application
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Youngest Age to Start Using
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Heartgard for Dogs
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Dogs
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Ivermectin
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None
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None
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oral
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6 weeks
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Heartgard Plus, Iverhart Plus, Iverhart Max, Triheart Plus, Pet Trust Plus
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Dogs
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Ivermectin
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Pyrantel Pamoate Iverhart Max also has Praziquantel
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Hookworms, Roundworms Iverhart Max also covers Tapeworms
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oral
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6 weeks
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Heartgard for Cats
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Cats
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Ivermectin
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None
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Hookworms
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oral
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6 weeks
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Interceptor, Milbeguard, Milbehart
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Dogs and Cats
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Milbemycin Oxime
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None
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Hookworms, Roundworms, Whipworms
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oral
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4 weeks for puppies 6 weeks for kittens
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Interceptor Plus
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Dogs
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Milbemycin Oxime
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Praziquantel
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Hookworms, Roundworms, Whipworms, Tapeworms
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oral
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6 weeks
(and at least 2 lbs)
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Sentinel, Sentinel Spectrum
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Dogs
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Milbemycin Oxime
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Lufenuron Sentinel Spectrum also has Praziquantel
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Hookworms, Roundworms, Whipworms, sterilizes Fleas Sentinel Spectrum also covers Tapeworms
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oral
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6 weeks
(and at least 2 lbs)
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Revolution, Paradyne, Revolt
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Dogs and Cats
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Selamectin
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None
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For dogs: Fleas, Ticks, Ear Mites, Sarcoptic Mange Mites
For Cats: Fleas, Ear Mites, Hookworms, Roundworms
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topical
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6 weeks for puppies 8 weeks for kittens
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Advantage Multi, Imoxi Topical
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Dogs and Cats
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Moxidectin
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Imidocloprid
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For dogs: Fleas, Hookworms, Roundworms, Whipworms
For Cats: Fleas, Ear Mites, Hookworms, Roundworms
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topical
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7 weeks for puppies 9 weeks for kittens
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Proheart6, Proheart12
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Dogs
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Moxidectin
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None
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Hookworms
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injectable
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6 months for Proheart6,
12 months for Proheart12
(and no older than 7 years)
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Trifexis
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Dogs
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Milbemycin Oxime
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Spinosad
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Fleas, Hookworms, Roundworms, Whipworms
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oral
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8 weeks
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| Coraxis |
Dogs
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Moxidectin
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None
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Roundworms, Hookworms, Whipworms
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topical
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7 weeks and at least 3 lbs
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How Often Used
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Approved for Pregnancy and Lactation?
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Water-proof?
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Safe to Give to Heartworm Positive Animal?
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Manufacturer Website
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LD50 what’s this?
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Heartgard for Dogs
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monthly
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yes
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yes
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yes
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Heartgard
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10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel
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Heartgard Plus, Iverhart Plus, Triheart Plus, Pet Trust Plus
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monthly
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yes
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yes
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yes
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Heartgard Plus Iverhart Plus Triheart Plus PetTrustPlus
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10 mg/kg in rats orally for ivermectin; >690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb
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Heartgard for Cats
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monthly
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yes
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yes
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yes
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Heartgard
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10 mg/kg in rats orally
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Interceptor, Milbeguard, Milbehart
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monthly
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yes
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yes
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In most cases yes but if microfilariae numbers are high then no
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Interceptor
Milbeguard
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LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
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Interceptor Plus
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monthly
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not tested for lactation, consult your vet regarding use in pregnancy
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yes
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In most cases yes but if microfilariae numbers are high then no
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Interceptor Plus
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LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
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Sentinel, Sentinel Spectrum
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monthly
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yes
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yes
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In most cases yes but if microfilariae numbers are high then no
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Sentinel
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LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
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Revolution, Paradyne, Revolt
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monthly
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yes
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yes
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yes
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Revolution
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>1600 mg/kg in the rat orally
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Advantage Multi, Imoxi Topical
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monthly
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no
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no
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yes
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Advantage Multi
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Moxidectin: 106 mg/kg orally; Imidocloprid: 450 mg/kg in the rat orally
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Proheart6, Proheart12
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every 6 months for Proheart6, every 12 months for Proheart12
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yes
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yes
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No, in fact owner must agree to pre-treatment labwork including heartworm testing
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Proheart6
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263 mg/kg in the rat when given by injection (the dose used therapeutically is 0.17mg/kg)
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Trifexis
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monthly
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Manufactuer cautions use, says to discuss with your veterinarian
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yes
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In most cases yes but if microfilariae numbers are high then no
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Trifexis
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Milbemycin Oxime: LD50 information unavailable Spinosad: >3,000 mg/kg in rats; >2,000 mg/kg in rabbits (translates to over 30 times recommended dose)
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Coraxis
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monthly
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no
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no
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yes
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BayerDVM
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106 mg/kg orally
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For a comparison of the anti-flea products
(Comfortis, Vectra 3D, Vectra for Cats, Promeris, Promeris Feline,
Revolution, Advantage, K9 Advantix, Advantage Multi,
Frontline, Frontline Plus, Program, Sentinel and Capstar),
click here.
For comparison of the anti-tick products
(K9 Advantix, Revolution, Promeris, Preventic Collar, Frontline and Vectra 3D)
click here.
Page last updated: 8/9/2021
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