For Dogs or Cats

Heartworm Preventing Ingredient

Other Ingredients for Control of Other Parasites

Other Parasites Controlled

Mode of Application

Youngest Age to Start Using

Heartgard for Dogs

Dogs

Ivermectin

None

None

oral

6 weeks

Heartgard Plus, Iverhart Plus, Iverhart Max, Triheart Plus, Pet Trust Plus

Dogs

Ivermectin

Pyrantel Pamoate Iverhart Max also has Praziquantel

Hookworms, Roundworms Iverhart Max also covers Tapeworms

oral

6 weeks

Heartgard for Cats

Cats

Ivermectin

None

Hookworms

oral

6 weeks

Interceptor, Milbeguard

Dogs and Cats

Milbemycin Oxime

None

Hookworms, Roundworms, Whipworms

oral

4 weeks for puppies 6 weeks for kittens

Interceptor Plus

Dogs

Milbemycin Oxime

Praziquantel

Hookworms, Roundworms, Whipworms, Tapeworms

oral

6 weeks
(and at least 2 lbs)

Sentinel, Sentinel Spectrum

Dogs

Milbemycin Oxime

Lufenuron Sentinel Spectrum also has Praziquantel

Hookworms, Roundworms, Whipworms, sterilizes Fleas Sentinel Spectrum also covers Tapeworms

oral

6 weeks
(and at least 2 lbs)

Revolution

Dogs and Cats

Selamectin

None

For dogs: Fleas, Ticks, Ear Mites, Sarcoptic Mange Mites
For Cats: Fleas, Ear Mites, Hookworms, Roundworms

topical

6 weeks for puppies 8 weeks for kittens

Advantage Multi

Dogs and Cats

Moxidectin

Imidocloprid

For dogs: Fleas, Hookworms, Roundworms, Whipworms
For Cats: Fleas, Ear Mites, Hookworms, Roundworms

topical

7 weeks for puppies 9 weeks for kittens

Proheart6

Dogs

Moxidectin

None

Hookworms

injectable

6 months (and no older than 7 years)

Trifexis

Dogs

Milbemycin Oxime

Spinosad

Fleas, Hookworms, Roundworms, Whipworms

oral

8 weeks

How Often Used

Approved for Pregnancy and Lactation?

Water-proof?

Safe to Give to Heartworm Positive Animal?

Manufacturer Website

LD50 what’s this?

Heartgard for Dogs

monthly

yes

yes

yes

Heartgard

10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel

Heartgard Plus, Iverhart Plus, Triheart Plus, Pet Trust Plus

monthly

yes

yes

yes

Heartgard Plus Iverhart Plus Triheart Plus PetTrustPlus

10 mg/kg in rats orally for ivermectin; >690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb

Heartgard for Cats

monthly

yes

yes

yes

Heartgard

10 mg/kg in rats orally

Interceptor, Milbeguard

monthly

yes

yes

In most cases yes but if microfilariae numbers are high then no

Interceptor
Milbeguard

LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose

Interceptor Plus

monthly

not tested for lactation, consult your vet regarding use in pregnancy

yes

In most cases yes but if microfilariae numbers are high then no

Interceptor Plus

LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose

Sentinel, Sentinel Spectrum

monthly

yes

yes

In most cases yes but if microfilariae numbers are high then no

Sentinel

LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose

Revolution

monthly

yes

yes

yes

Revolution

>1600 mg/kg in the rat orally

Advantage Multi

monthly

no

no

yes

Advantage Multi

Moxidectin: 106 mg/kg orally; Imidocloprid: 450 mg/kg in the rat orally

Proheart6

every 6 months

yes

yes

No, in fact owner must agree to pre-treatment labwork including heartworm testing

Proheart6

263 mg/kg in the rat when given by injection (the dose used therapeutically is 0.17mg/kg)

Trifexis

monthly

Manufactuer cautions use, says to discuss with your veterinarian

yes

In most cases yes but if microfilariae numbers are high then no

Trifexis

Milbemycin Oxime: LD50 information unavailable  Spinosad: >3,000 mg/kg in rats; >2,000 mg/kg in rabbits (translates to over 30 times recommended dose)