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Heartworm Comparison
Confused about Heartworm prevention options? These two charts compare current heartworm preventive products side by side to assist you in determining which is right for your situation.
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For Dogs or Cats
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Heartworm Preventing Ingredient
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Other Ingredients for Control of Other Parasites
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Other Parasites Controlled
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Mode of Application
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Youngest Age to Start Using
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Heartgard for Dogs
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Dogs
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Ivermectin
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None
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None
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oral
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6 weeks
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Heartgard Plus, Iverhart Plus, Iverhart Max, Triheart Plus, Pet Trust Plus
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Dogs
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Ivermectin
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Pyrantel Pamoate Iverhart Max also has Praziquantel
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Hookworms, Roundworms Iverhart Max also covers Tapeworms
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oral
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6 weeks
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Heartgard for Cats
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Cats
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Ivermectin
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None
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Hookworms
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oral
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6 weeks
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Interceptor, Milbeguard, Milbehart
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Dogs and Cats
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Milbemycin Oxime
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None
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Hookworms, Roundworms, Whipworms
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oral
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4 weeks for puppies 6 weeks for kittens
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Interceptor Plus
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Dogs
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Milbemycin Oxime
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Praziquantel
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Hookworms, Roundworms, Whipworms, Tapeworms
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oral
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6 weeks
(and at least 2 lbs)
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Sentinel, Sentinel Spectrum
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Dogs
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Milbemycin Oxime
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Lufenuron Sentinel Spectrum also has Praziquantel
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Hookworms, Roundworms, Whipworms, sterilizes Fleas Sentinel Spectrum also covers Tapeworms
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oral
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6 weeks
(and at least 2 lbs)
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Revolution, Paradyne, Revolt
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Dogs and Cats
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Selamectin
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None
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For dogs: Fleas, Ticks, Ear Mites, Sarcoptic Mange Mites
For Cats: Fleas, Ear Mites, Hookworms, Roundworms
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topical
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6 weeks for puppies 8 weeks for kittens
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Advantage Multi, Imoxi Topical
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Dogs and Cats
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Moxidectin
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Imidocloprid
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For dogs: Fleas, Hookworms, Roundworms, Whipworms
For Cats: Fleas, Ear Mites, Hookworms, Roundworms
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topical
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7 weeks for puppies 9 weeks for kittens
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Proheart6, Proheart12
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Dogs
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Moxidectin
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None
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Hookworms
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injectable
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6 months for Proheart6,
12 months for Proheart12
(and no older than 7 years)
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Trifexis
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Dogs
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Milbemycin Oxime
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Spinosad
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Fleas, Hookworms, Roundworms, Whipworms
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oral
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8 weeks
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| Coraxis |
Dogs
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Moxidectin
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None
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Roundworms, Hookworms, Whipworms
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topical
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7 weeks and at least 3 lbs
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Simparica Trio
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Dogs
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Moxidectin
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Sarolaner,
pyrantel pamoate
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fleas, ticks, roundworms, hookworms
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oral
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8 weeks, 2.8 lbs
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| Bravecto Plus |
Cats
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Moxidectin
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Fluralaner (for fleas and ticks)
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ticks, fleas, hookworms, roundworms
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topical
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6 months
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How Often Used
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Approved for Pregnancy and Lactation?
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Water-proof?
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Safe to Give to Heartworm Positive Animal?
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Manufacturer Website
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LD50 what’s this?
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Heartgard for Dogs
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monthly
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yes
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yes
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yes
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Heartgard
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10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel
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Heartgard Plus, Iverhart Plus, Triheart Plus, Pet Trust Plus
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monthly
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yes
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yes
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yes
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Heartgard Plus Iverhart Plus Triheart Plus PetTrustPlus
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10 mg/kg in rats orally for ivermectin; >690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb
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Heartgard for Cats
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monthly
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yes
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yes
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yes
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Heartgard
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10 mg/kg in rats orally
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Interceptor, Milbeguard, Milbehart
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monthly
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yes
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yes
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In most cases yes but if microfilariae numbers are high then no
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Interceptor
Milbeguard
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LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
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Interceptor Plus
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monthly
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not tested for lactation, consult your vet regarding use in pregnancy
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yes
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In most cases yes but if microfilariae numbers are high then no
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Interceptor Plus
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LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
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Sentinel, Sentinel Spectrum
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monthly
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yes
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yes
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In most cases yes but if microfilariae numbers are high then no
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Sentinel
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LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
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Revolution, Paradyne, Revolt
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monthly
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yes
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yes
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yes
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Revolution
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>1600 mg/kg in the rat orally
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Advantage Multi, Imoxi Topical
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monthly
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no
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no
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yes
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Advantage Multi
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Moxidectin: 106 mg/kg orally; Imidocloprid: 450 mg/kg in the rat orally
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Proheart6, Proheart12
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every 6 months for Proheart6, every 12 months for Proheart12
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yes
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yes
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No, in fact owner must agree to pre-treatment labwork including heartworm testing
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Proheart6
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263 mg/kg in the rat when given by injection (the dose used therapeutically is 0.17mg/kg)
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Trifexis
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monthly
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Manufactuer cautions use, says to discuss with your veterinarian
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yes
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In most cases yes but if microfilariae numbers are high then no
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Trifexis
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Milbemycin Oxime: LD50 information unavailable Spinosad: >3,000 mg/kg in rats; >2,000 mg/kg in rabbits (translates to over 30 times recommended dose)
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Coraxis
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monthly
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no
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no
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yes
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BayerDVM
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106 mg/kg orally
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Simparica Trio
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monthly
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no
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yes
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no
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Zoetis
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783 mg/kg for rats (oral)
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Bravecto Plus
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every 2 months
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no
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no
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manufacturer recommends use with caution
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Merk Animal Health
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Fluralaner: Dermal LD50: >2000 mg/kg (rat), Oral LD50: >2000 mg/kg (rat)
Moxidectin: 106 mg/kg orally
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For a comparison of the anti-flea products
(Comfortis, Vectra 3D, Vectra for Cats, Promeris Feline,
Revolution, Advantage, K9 Advantix, Advantage Multi,
Frontline, Frontline Plus, Program, Sentinel and Capstar),
click here.
For comparison of the anti-tick products
(K9 Advantix, Revolution, Promeris, Preventic Collar, Frontline and Vectra 3D)
click here.
Page last updated: 8/12/2022
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