GRAM NEGATIVE EAR INFECTIONS IN DOGS

(original graphic by marvistavet.com)

Anything that facilitates ear wax accumulation, sets the stage for ear infection. It might be irritation from water in the ear canal after a bath, narrowed ear canal typical of certain breeds, or actual disease causing over-production of ear wax. Allergic skin disease affecting the ears is the most common cause for recurring increased ear wax production/ear infection; other causes of ear infections include ear mites, and foreign bodies in the ear (such as grass awns or foxtails), or hair growth deep in the canal (common in poodles and schnauzers especially). The moisture of the wax promotes bacterial growth, yeast proliferation, and perhaps even pus development. It isn’t long before the pet is seen scratching at his or her ears, shaking his or her head or holding one ear slightly dropped. Discharge and odor may be noticeable to the owner.

GRAM NEGATIVE INFECTIONS ARE SPECIAL

The Gram negative ear infection is a special situation. The ear discharge has less waxy and more pus. It is extra smelly, extra painful, and sometimes actually ulcerative. Gram negative bacteria (so named because they do not take up Gram stain when viewed under the microscope), tend to have unpredictable antibiotic profiles which makes them harder to treat. They are frequently resistant to commonly used ear products. Using ineffective antibiotics just leads to broader antibiotic resistance. This is how the "superbugs" we periodically read about in the news come to be.

Gram negative ear infections are extra uncomfortable and extra challenging.

PSEUDOMONAS INFECTION (AN EVEN WORSE GRAM NEGATIVE INFECTION) There is a particularly heinous bacterial species that is almost always resistant to most conventional antibiotics from the beginning and it deserves special mention: Pseudomonas aeruginosa. When ear cytology samples reveal a Gram negative infection, culture is recommended as treatment for Pseudomonas but must be definitive. Pseudomonas should be identified as soon as possible as every ineffective attempt at treatment generally makes it more resistant. One might wonder how such a difficult bacterium comes to be present in a given ear. Sometimes a dog is just unlucky but often Pseudomonas infection happens in ears that have been treated repeatedly for ear infections in the past. The unfortunate tendency is for normal ear bacteria to be killed off with each treatment course leaving only the most resistant bacteria to colonize the ear canal. Pseudomonas readily grows and prospers where less resistant bacteria have been cleared.

Gram negative bacteria such as Pseudomonas aeruginosa shown above, look like tiny pink dots under the microscope. (Photo credit: CDC Public Image Library)

If one is lucky, a culture of the ear discharge will reveal that the Pseudomonas is still sensitive to a quinolone antibiotics such as enrofloxacin, marbofloxacin, or orbifloxacin. It should be noted that especially high doses of this type of antibiotic are needed to treat Pseudomonas in the ear and that inadequate dosing will just make Pseudomonas even more resistant. Therapy must be decisive.

If one is not as lucky, culture may show there are no effective antibiotics against a particular Gram negative infection. In this situation, disinfectant rinses may be the only choice. Oral antibiotics may be prescribed as well though there is controversy at this time about whether the approach to ear infections, even resistant ones, should be treated only with topical therapy.

COMPLICATIONS OF GRAM NEGATIVE EAR INFECTION

MIDDLE EAR INFECTION

A routine ear infection is uncomfortable enough but if the infection persists, it can become an even bigger problem. The infection can lead to proliferation and scarring in the canal which makes the infection especially difficult (and potentially impossible) to clear up. The ear canal may mineralize and the middle ear may come to be involved, leading to nerve damage. Affected animals may have a head tilt, a lack of balance, and unusual back-and-forth eye movements (called “nystagmus.”) These symptoms are called “vestibular signs” and represent a special complication of middle ear infection. Middle ear infections can also cause paralysis of the facial nerve, leading to a slack-jawed appearance on that side of the face.

Severe cases may require surgical intervention to flush through the ear drum, open up the bones around the internal ear structures, revise the conformation of the ear canal (lateral ear resection) or even remove and seal the ear canal in extreme cases (ear canal ablation). Of course, the goal is to control ear infection recurrence before this stage is ever reached.

TREATMENT OF EAR INFECTIONS

LEVEL ONE: THE SIMPLE EAR INFECTIONS

Most ear infections are cleared up simply with professional cleaning followed by medication at home. If only mild debris is present in the ear canals, simple disinfection and washing of the ear is adequate; however, in many cases, a full ear flush is needed to even examine the eardrum. For patient comfort, we recommend sedation for this procedure as the ears are sore and the instruments can be damaging if the pet jumps at the wrong time. A sample of ear discharge is commonly examined under the microscope so as to assist in selecting medications for home use. After a couple of weeks of home treatment, the ear canals are rechecked to be sure the infection is gone. In most cases this completes treatment but for stubborn cases, we must proceed to the next step.

LEVEL TWO: ON-GOING EAR INFECTIONS

Some dogs have chronic ear problems (the infection is not controlled by general medication or returns when general medication is discontinued). In these cases, the ear discharge should be cultured so that the precise organism can be pinpointed and treated specifically. Regular treatment at home with disinfecting ear washes should become part of the pet's grooming routine.

Further testing may be in order to determine why the infection continues to recur. Allergy is the most common reason for recurrent ear problems but hormone imbalances can also be underlying causes.

LEVEL THREE: THE END-STAGE EAR

 Ear infections are common and can be challenging. Fortunately, most cases are simple and easily cleared up. Be sure to recheck the ears as your veterinarian recommends as premature discontinuance of treatment can lead to a continuing infection.

Gram negative ear infections do not have the same kind of leeway that other ear infections do. It is crucial that recheck appointments are not skipped because Gram negatives will simply get harder to clear if treatment is incomplete. Your veterinarian will need to confirm that the infection is resolved fully before medication can be withdrawn.

Page last updated: 9/14/2024

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