(for veterinary information only)
BRAND NAME: SIMPLICEF, VANTIN
The Cephalosporin class of antibiotics was developed to improve upon the accomplishments of the Penicillin class. The first group of cephalosporins to be developed was the so-called "First Generation Cephalosporins" which are effective against most Gram positive infections, some Gram negative infections and are able to withstand the anti-penicillin enzymes produced by Staphylococci. This was a wonderful thing but there was demand for more activity against Gram negative infections so a second and finally a third generation of cephalosporins emerged, each generation with greater ability to prevail against Gram negative bacteria. Cefpodoxime is a third generation cephalosporin and one of the few that can be administered orally. It was released for veterinary use in the earlier part of 2005.
HOW THIS MEDICATION IS USED
The beauty of cefpodoxime is twofold: it is available for oral use AND it is given only once a day. Its recommended dosing schedule is flexible with lower doses recommended for tissues where the drug is readily concentrated (such as in urine for treatment of a bladder infection, or abscesses/wounds) and higher ones for tissues where the drug is not as well concentrated (such as ear infections). Because of its ability to treat more complicated infections, it is often selected for jobs where other antibiotics are expected to fail. Since its release as a veterinary product it has gained popularity especially in veterinary dermatology where Staphylococcal infections are common and treatment durations of several weeks are routine.
Cefpodoxime can be given on a full or empty stomach with no change in efficacy.
Approximately 2% of dogs taking this medication experience vomiting, 1% experience diarrhea, and 1% experience reduced appetite.
INTERACTIONS WITH OTHER DRUGS
Drugs that decrease stomach acidity (any antacids) may decrease absorption and thus efficacy of cefpodoxime.
CONCERNS AND CAUTIONS
Page last updated: 9/8/2018