TETANUS IN PETS
We have all heard of tetanus shots and have some sense that we are supposed to periodically get them, especially after exposure to some sort of dirty wound or bite. Some of us may even know that tetanus is sometimes referred to as “lock jaw” but the general knowledge of tetanus usually does not extend much beyond that. Most people are not aware that tetanus is a problem for animals as well as people (though horse owners are probably all too familiar with tetanus).
Tetanus is a disease caused by a toxin secreted by a bacterium known as Clostridium tetani, one of many toxin-secreting Clostridia. These bacteria are anaerobic, meaning that they grow in conditions where there is no oxygen (such as a deep bite wound or puncture). Clostridiaare soil bacteria, meaning that they live in dirt so it should be easy to see how a puncture contaminated with dirt would be the classical tetanus-yielding wound. Such wounds are particularly common on farms where there might be nails or bits of wire on the ground, ready to pierce a human or animal foot, but there is nothing special about rusted metal in predisposing to tetanus. The puncture can come from any pointed object. The pointy object provides the puncture (an anaerobic wound) and contamination with dirt provides the Clostridia. A fight involving a bite wound and rolling around in dirt might similarly offer an opportunity for tetanus.
THE TOXIN AND WHAT IT DOES
The tetanus toxin is called “tetanospasmin.” It is produced by the bacterium Clostridium tetani in a wound. The toxin binds to local nerves and migrates up into the central nervous system where it interferes with the release of glycine, an amino acid that also acts as an inhibitory neurotransmitter. The result of this loss of inhibition is painful muscle over-activity, spasms and rigidity. In severe cases, the patient cannot breathe because of the rigid paralysis of the respiratory muscles and a mechanical ventilator is required. In humans most deaths from tetanus occur in infants and in the elderly though with proper intensive care mortality is only 10-15%.
Classically, the patient loses his or her ability to blink and must flash the third eyelid to moisten the eye. The patient becomes sensitive to light and sound such that clapping one’s hands can actually create spasms or seizures. Dogs with ears that hang down may actually develop ears that stand up straight, and the facial muscles pull back in such a way as to create what is called the “risus sardonicus” or “sardonic smile.” In more advanced stages, the patient can no longer walk and stands stiffly in what is called a “sawhorse stance.” Initial signs seem to pertain to the eyes and can easily be mistaken for eye disease in the early stages.
Sometimes tetanus can be partial where only the group of muscles local to the initial wound are involved. The muscles become stiff and can exhibit tremoring. This form may or may not generalize to the whole body. Because dogs have a natural resistance to tetanus, this partial or localized form is more common than full body involvement.
Classically there is a history of a wound in a tetanus case (generally in the preceding 1-2 weeks)
There is no test for tetanus in the way one might hope: no blood test, or unique finding. The diagnosis is generally made based on the appearance of the animal and history of a wound. It is possible to measure antibody levels against the tetanus toxin but this has not been widely used in the clinical setting. Attempting to culture Clostridium tetani from the wound is generally not successful.
The first step in treatment is antibiotic therapy to kill the Clostridia. Happily, unusual antibiotics are not needed: penicillin works quite well for this classical gram positive rod. Ampicillin, a newer generation penicillin (though now hardly new at all) is not nearly as effective though tetracycline could be used as an alternative. Metronidazole is felt to be more effective still, though has more side effects potential with long term use.
Sedation is necessary to control the spasms and/or seizures. Acepromazine and chlorpromazine have been recommended to control the sensitivity to light and noise. These medications can promote seizures in other sets of circumstances but tetanus is the exception to this rule. Injectable pentobarbital, phenobarbital, or diazepam can be used to control the muscles stiffness.
The decision on whether or not to include tetanus antitoxin is more controversial. Antitoxin is an antibody solution (a blood product) generated by either a horse or human to bind and destroy the tetanus toxin. It cannot remove toxin already bound to the patient’s nerves but can inactivate new toxin not yet bound. Toxin that is already bound to nerves simply has to unbind in time on its own. The risk of antitoxin stems from the fact that it is a blood product of another species and highly inflammatory to the immune system. Antitoxin can be given under the skin or in the muscle but can take up to 3 days to reach a therapeutic level this way. An IV administration is more rapid but also more dangerous in terms of inducing an anaphylactic reaction. Skin testing is commonly used to see how reactive the patient might be.
Tetanus toxoid is the “tetanus shot” most of us have had at one time or another. It is a vaccine against the tetanus toxin and it is part of a horse’s regular vaccination set (just as it is part of a human’s vaccination set). Because dogs and cats are much more resistant to tetanus than are horses and humans, regular vaccination against tetanus is not recommended for them.
Nursing care requires a darkened room with minimal stimulation even if the pet no longer requires hospitalization. Clenched jaws can be problematic for feeding so expect a liquid diet or slurry to be needed. Soft bedding to prevent bedsores is a must. Improvement is generally noted within the first week of therapy but complete recovery can easily take a month.
Most of the information presented here has been gleaned from a study by Burkitt et al published in the Journal of the American Veterinary Medical Association in January 2007 where 35 cases of canine tetanus seen at the University of California Veterinary Teaching hospital were reviewed for analysis.
For the purposes of the study mentioned above, cases were classified by the severity of their signs into four groups. It is important to realize that a dog’s initial classification could easily change (in fact, in this study 17 dogs that were normal or in Group I at the beginning of the study, ended in Group III or IV).
The dog was able to walk but also demonstrated constricted pupils, risus sardonicus, erect ears, inability to open its jaws, sunken eyes, and/or sensitivity to light.
All of the above plus erect tail, sawhorse stance, difficulty swallowing, walking stiffly with difficulty.
All of the above plus muscle tremors or spasms, inability to walk, and seizures.
All of the above plus any of the following: heart rate below 60 beats per minute, heart rate above 140 beats per minute, high blood pressure, low blood pressure or respiratory arrest.
Overall, of the 35 dogs included in this study, 77% survived. All the dogs that never progressed beyond severity Group II survived and 50% of the dogs in Groups III and IV survived. Dogs in these latter two Groups required continuous care (intravenous fluids, sedation, nutritional support etc.)
WATCH THE VIDEO PRESENTATION ON TETANUS SHOWING CHARACTERISTICS SYMPTOMS:
Page last updated: 7/1/2017