(for veterinary information only)
BRAND NAME: ORBAX
USES OF THIS MEDICATION
This medication may be used in either dogs or cats to combat different types of infections, especially those involving Pseudomonas. Orbifloxacin is also active against Staphylococci, and thus is commonly used for infections of the skin. Orbifloxacin has poor activity against anaerobic infections (such as are typical in the mouth or in bite wound abscesses.)
At approximately ten times the recommended dose vomiting and diarrhea may be seen with this medication. At normal doses, this should not be seen. Dogs with Pseudomonas ear infections require very high doses of orbifloxacin and nausea may indeed become a problem.
In immature dogs (less than 8 months of age) damage to joint cartilage can occur. This phenomenon is only seen in growing dogs and does not seem to be a problem in cats. It is preferable not to use this medication in puppies unless the severity of the infection present warrants it.
Orbifloxacin promotes nervous system stimulation and should be used with caution or not at all in patients with seizure disorders.
The recently described problem with blindness in cats associated with higher doses of enrofloxacin has not been confirmed in orbifloxacin. Orbifloxicin has a slightly different chemical structure which leads to less drug accumulation in the feline eye but potential for problems at higher doses has not been fully investigated.
INTERACTIONS WITH OTHER DRUGS
Sucralfate (a medication used to treat stomach ulcers) may bind orbifloxacin and prevent it from entering the body. These medications should be given at least 2 hours apart if they are used together.
Theophylline (an airway dilator) blood levels may be higher than usual if this medication is used concurrently with orbifloxacin. The dose of theophylline may need to be reduced.
Medications or supplements containing iron, zinc, magnesium or aluminum will bind orbifloxacin and prevent absorption into the body. Such medications should be separated from orbifloxacin by at least 2 hours.
Orbifloxacin can synergize with other antibiotics (making their combined effect greater than expected from simply adding their two effects together). Commonly used antibiotics felt to synergize with orbifloxacin include extended spectrum penicillins (such as amoxicillin) and third generation cephalosporins (such as cefpodoxime).
CONCERNS AND CAUTIONS
Orbifloxacin tablets are enteric coated to hide the drug's naturally bitter taste. If the tablets are crushed for some reason, the bitter taste is more readily apparent. Crushing tablets to put in an animal's food is unlikely to be an effective way to administer orbifloxacin.
Pseudomonas infections are especially common in ears. In this location, especially high doses of orbifloxacin are needed to clear this infection.
Orbifloxacin should be avoided in pregnant, or nursing pets nor in immature dogs unless the severity of the infection warrants it (because of the potential damage that can occur to developing cartilage as mentioned above).
Orbifloxacin may lower the seizure threshold (meaning that it can facilitate seizures). This is not a problem for normal animals but fluoroquinolones are best not used in animals with known seizure disorders.
Orbifloxacin is best given on an empty stomach but may be given with a small amount of non-dairy food if nausea is a concern.
Page last updated: 1/7/2017