Heartworm Preventive Comparison

Confused about Heartworm prevention options? This chart compares current heartworm preventive products side by side to assist you in determining which is right for your situation.

 

Heartgard
for Dogs

Heartgard Plus
Iverhart Plus
Triheart Plus

Heartgard
for Cats

Interceptor

Sentinel

Revolution

Advantage Multi

Heartworm Preventing Ingredient

Ivermectin

Ivermectin

Ivermectin

Milbemycin Oxime

Milbemycin Oxime

Selamectin

Moxidectin

Other Ingredients for Control of Other Parasites

None

Pyrantel
Pamoate

None

None

None

None

Imidocloprid

Other Parasites Controlled

None

Hookworms,
Roundworms

Hookworms

Hookworms,
Roundworms,
Whipworms

Hookworms,
Roundworms,
Whipworms,
sterilizes Fleas

For dogs:
Fleas, Ticks,
Ear Mites, Sarcoptic Mange Mites
For Cats:
Fleas,
Ear Mites, Hookworms, Roundworms

For dogs:
Fleas,
Hookworms,
Roundworms,
Whipworms
For Cats:
Fleas,
Ear Mites,
Hookworms,
Roundworms

Mode of Application

oral

oral

oral

oral

oral

topical

topical

Youngest Age to Start Using

6 weeks

6 weeks

6 weeks

4 weeks
for puppies
6 weeks
for kittens

4 weeks

6 weeks
for puppies
8 weeks
for kittens

7 weeks
for puppies
9 weeks
for kittens

Approved for Pregnancy and Lactation?

yes

yes

yes

yes

yes

yes

no

Waterproof?

yes

yes

yes

yes

yes

yes

no

Safe to Give to Heartworm Positive Animal?

yes

yes

yes

In most cases yes but if microfilariae numbers are high then no

In most cases yes but if microfilariae numbers are high then no

yes

yes

Manufacturer Website

Heartgard

Heartgard Plus
Iverhart Plus
Triheart Plus

Heartgard

Interceptor

Sentinel

Revolution

Advantage
Multi

LD50
what’s this?

10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel

10 mg/kg in rats orally for ivermectin; >690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb

10 mg/kg in rats orally

LD50 information unavailable

Symptoms of tremors and incoordination result at 19 times recommended dose

LD50 information unavailable

Symptoms of tremors and incoordination result at 19 times recommended dose

>1600 mg/kg in the rat orally

Moxidectin
106 mg/kg orally;
Imidocloprid
450 mg/kg in the rat orally

For a comparison of the anti-flea products
Advantage, Frontline and Revolution, click here.

Page last updated: 3/12/08