Confused about Heartworm prevention options? This chart compares current heartworm preventive products side by side to assist you in determining which is right for your situation.

	Heartgard for Dogs	Heartgard Plus Iverhart Plus Triheart Plus	Heartgard for Cats	Interceptor	Sentinel	Revolution	Advantage Multi
Heartworm Preventing Ingredient	Ivermectin	Ivermectin	Ivermectin	Milbemycin Oxime	Milbemycin Oxime	Selamectin	Moxidectin
Other Ingredients for Control of Other Parasites	None	Pyrantel Pamoate	None	None	None	None	Imidocloprid
Other Parasites Controlled	None	Hookworms, Roundworms	Hookworms	Hookworms, Roundworms, Whipworms	Hookworms, Roundworms, Whipworms, sterilizes Fleas	For dogs: Fleas, Ticks, Ear Mites, Sarcoptic Mange Mites For Cats: Fleas, Ear Mites, Hookworms, Roundworms	For dogs: Fleas, Hookworms, Roundworms, Whipworms For Cats: Fleas, Ear Mites, Hookworms, Roundworms
Mode of Application	oral	oral	oral	oral	oral	topical	topical
Youngest Age to Start Using	6 weeks	6 weeks	6 weeks	4 weeks for puppies 6 weeks for kittens	4 weeks	6 weeks for puppies 8 weeks for kittens	7 weeks for puppies 9 weeks for kittens
Approved for Pregnancy and Lactation?	yes	yes	yes	yes	yes	yes	no
Waterproof?	yes	yes	yes	yes	yes	yes	no
Safe to Give to Heartworm Positive Animal?	yes	yes	yes	In most cases yes but if microfilariae numbers are high then no	In most cases yes but if microfilariae numbers are high then no	yes	yes
Manufacturer Website	Heartgard	Heartgard Plus Iverhart Plus Triheart Plus	Heartgard	Interceptor	Sentinel	Revolution	Advantage Multi
LD50 what’s this?	10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel	10 mg/kg in rats orally for ivermectin; >690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb	10 mg/kg in rats orally	LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose	LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose	>1600 mg/kg in the rat orally	Moxidectin 106 mg/kg orally; Imidocloprid 450 mg/kg in the rat orally

For a comparison of the anti-flea products
Advantage, Frontline and Revolution, click here.

Page last updated: 3/12/08