Demodectic Mange

(SOMETIMES CALLED
"RED MANGE" OR “DEMODICOSIS”)

THE CULPRIT - DEMODEX CANIS

animated demodex1Demodectic mange, also called "demodicosis," is caused by a microscopic mite of the Demodex genus. Three species of Demodex mites have been identified in dogs: Demodex canis, Demodex gatoi, and Demodex injai. The most common mite of demodectic mange is Demodex canis. All dogs raised normally by their mothers possess this mite as mites are transferred from mother to pup via cuddling during the first few days of life. Most dogs live in harmony with their mites, never suffering any consequences from being parasitized. If, however, conditions change to upset the natural equilibrium (such as some kind of suppression of the dog's immune system), the Demodex mites may "gain the upper hand." The mites proliferate and can cause serious skin disease.

IS DEMODICOSIS CONTAGIOUS?

Demodectic mange (unlike Sarcoptic mange) is not considered a contagious disease and isolation of affected dogs is generally not considered necessary. That said, there are some circumstances under which the mites could spread from one dog to another. Classically Demodex mites have been felt to only be transferable from mother to newborn pup. After the pup is a week or so old, it has developed enough immunity so that infection is no longer possible. In other words, after age one week or so, a dog will not longer accept new mites on its body. Recently this idea has been challenged as occasionally multiple unrelated dogs break with demodicosis in the same household. It is not clear if some species of Demodex are more contagious than others or if some contagion is possible under certain circumstances. Current thinking is that mites actually can be transferred from one dog to another but as long as the dog is healthy, the mites simply add into the dog's natural mite population and no skin disease results. In rare circumstances contagion is possible if a very severe infection is involved. While there are still assorted theories about dog to dog transmission of Demodex mites, there is no question that mites cannot be transmitted to humans or to cats.

  • Mites live inside hair follicles -- a difficult place for miticides (chemicals that kill mites) to reach.
     
  • Mites are a normal residents of dog skin; it is only in some individual dogs that mites cause problems.

DEMODICOSIS HAS THREE FORMS

FORM #1: LOCALIZED

mange1Localized demodicosis occurs as isolated scaly bald patches, usually on the dog's face, creating a polka-dot appearance. Localized demodicosis is considered a common puppyhood ailment and approximately 90% of cases resolve with no treatment of any kind. This is quite a contrast to generalized demodicosis as described below so it is important to be able to distinguish localized from generalized disease. It seems like this would be a simple task since localized demodicosis classically involves several round facial bald spots and generalized demodicosis involves a bald scaly entire dog; still, reality does not always fit into neat categories in this way. Some guidelines used to distinguish localized demodicosis include:

  • Localized disease does not involve more than two body regions. (One spot or two on the face and one spot or two on a leg would still qualify as localized even though the spots are not close together.)
     
  • Localized disease involves no more than 4 spots total on the dog.

Blacki Larabaldivia localized demodex

Puppy with localized demodicosis
around her left eye

Treatment is not necessary or recommended for localized demodicosis but there are treatment options for people who simply cannot feel right about doing nothing. Goodwinol ointment, an insecticide ointment, may be used daily to control localized demodicosis. Antibacterial gels are also used against localized demodicosis and associated skin infections. It is important to note that rubbing a creme or ointment on a demodicosis lesion can cause reddening of the lesion making it appear to get worse. It is also possible for rubbing the medication on the area to break off the weaker hairs at the margin of the lesion causing the lesion to appear to get bigger. Neither of these situations truly represents exacerbation of the disease.

Resolution of a localized demodicosis lesion should be at least partially apparent after one month though total resolution can take up to three months.

Approximately 10% of localized demodicosis cases will progress to generalized demodicosis. Enlarged lymph nodes are a bad sign -- often foretelling generalized mange.

CAN THE PUP BE BRED LATER?

Sometimes the puppy with localized demodicosis was obtained for breeding purposes. The current recommendation is not to treat these puppies so that we can determine if the condition will stay localized and resolve or if it will generalize. If it stays localized and eventually resolves without treatment, the animal is still a candidate for breeding. If the condition generalizes to cover the entire body, the animal should be sterilized. If the condition receives treatment and resolves, we will never know how the disease would have gone in its natural state and will not know whether the pup is carrying the genetic predisposition for generalized demodectic mange. In this case, it is best to be conservative and not take the chance of passing on genetic predisposition for this disease.

Localized demodicosis is almost exclusively a "puppyhood" disease. When a puppy develops localized demodicosis the chance of the condition resolving is 90% unless there is a family history of demodicosis in related dogs. In this case, chance of spontaneous resolution drops to 50%.

Occasionally an adult dog develops localized demodicosis. We currently do not have good understanding of the prognosis or significance of this condition in an adult dog.

Mandy WSGSR Demodectic Mange

Dog with generalized demodicosis

FORM #2: GENERALIZED

Classically with generalized demodicosis, the entire dog is affected with patchy fur, skin infections, bald, scaly skin. Sometimes large patches of affected skin are present, sometimes multiple "polka dots" of lesions cover the dog, and sometimes the entire body is involved. The secondary bacterial infections make this a very itchy and often smelly skin disease. The approach to generalized demodicosis typically depends on the age at which the dog developed the disease.

ADULT ONSET-- Most demodicosis occurs in young dogs, under age one and a half. An older dog should not get demodicosis unless he or she has an underlying problem with the immune system. In such cases, demodicosis is considered a indication to seek a more serious hidden condition such as cancer, liver or kidney disease, or an immune-suppressive hormone imbalance. A more extensive medical work-up will be required.

JUVENILE ONSET -- Young dogs have inherently immature immune systems and are thus susceptible to the development of demodicosis without any sinister underlying diseases. As they grow up and their immune systems mature, they tend to naturally gain control of their mite infestation; in fact, 30-50% of dogs under age 1 year recover spontaneously from generalized demodicosis without any form of treatment. Usually treatment is recommended, though, to facilitate recovery.

IT IS VERY IMPORTANT THAT DOGS WITH A HISTORY OF GENERALIZED
DEMODECTIC MANGE NOT BE BRED AS THERE IS A HEREDITARY
COMPONENT TO THE DEVELOPMENT OF THE DISEASE.

FORM #3: DEMODECTIC PODODERMATITIS

mange3This condition represents demodectic mange confined to the paws. Bacterial infectious usually accompany this condition. Often as generalized demodicosis is treated, the foot is the last stronghold of the mite. Old English Sheepdogs and Shar pei tend to get severe forms of this condition. The infection can be so deep that biopsy is needed to find the mites and make the diagnosis. It is one of the most resistant forms of demodicosis.

TREATMENT: STRESS AND GENERALIZED DEMODECTIC MANGE

The treatment of demodicosis only in part relies on medications; some basic steps can be taken with regard to pet care to maximize the chance of success. Physiological stress is an important factor determining the degree of severity of demodectic mange and the following steps should be taken to reduce stress:

  1. Females should be spayed as soon as the disease is controlled. Coming into heat, hormone fluxes, and pregnancy are very stressful and will encourage the mites. Also, predisposition to demodicosis is hereditary and should not be passed on.
     
  2. The dog should be fed a reputable brand of dog food so as to avoid any nutritionally related problems.
     
  3. Keep the pet parasite-free. Worms are irritants that the pet need not deal with and fleas may exacerbate the itchiness and skin infection.
     
  4. Keep up the pet's vaccinations.
     
  5. The mites themselves cause suppression of the immune system so the pet needs every advantage to stay healthy.
     
  6. Skin infections are usually present in these cases and antibiotics will likely be necessary. It is very important that cortisone type medications such as prednisone NOT be used in these cases as they will tip the immune balance in favor of the mite.

TREATMENT: MEDICATIONS

CURRENT TREATMENT OF CHOICE -- IVERMECTIN

Ivermectin is a broad spectrum anti-parasite medication with a number of uses though
its use in treating demodicosis is not approved by the FDA. When ivermectin was a new drug it was hoped that it could be used against demodectic mange mites as at that time only fairly toxic dips were available and incurable cases were common. After some experimentation it was found that daily or every other day dosing is necessary for effective demodicosis treatment and soon ivermectin was felt unequivocally to be the drug of choice for this condtion. Note that the weekly protocols that work for other parasites simply do not work on Demodex mites.

Ivermectin is inexpensive relative to Milbemycin (see below) and involves no labor intensive bathing. It DOES, however, taste terrible if given orally (it may be necessary for the owner to learn how to give ivermectin as an injectable treatment.) There is, unfortunately, an important occasional problem that keeps other treatment options listed: drug sensitivity. Some individual dogs are sensitive to ivermectin and can die if subjected to a typical therapeutic dose for demodicosis.

THIS MEDICATION CANNOT BE ASSUMED SAFE FOR USE
IN COLLIES, SHETLAND SHEEPDOGS, AUSTRALIAN SHEPHERDS,
OLD ENGLISH SHEEPDOGS AND,
SOME WOULD SAY, ANY HERDING BREED.

No Collie

No Australian Shepherd

No Old English Sheepdog

No Border Collie

Sensitivity to ivermectin may not be predictably limited to “collie breeds” and thus it is often prudent to use a lower test dose before initiating the relatively high doses of ivermectin needed to treat demodicosis. Not all individuals of collie heritage are sensitive to ivermectin and a test is now available through Washington State University to determine whether an individual should be able to safely take ivermectin or not. An alternative to testing is to use a low test dose for a period of time and watch for mild side effects. If there is any question about your pet’s potential sensitivity to ivermectin, your veterinarian will instruct you.

For details on testing for ivermectin sensitivity visit:

www.vetmed.wsu.edu/depts%2Dvcpl/

There is a range of ivermectin doses used in the treatment of demodicosis and it seems that higher doses do clear infection faster than lower doses. This means that if a lower dose has been ineffective, a higher dose may still work. This does not mean that a pet owner should experiment with ivermectin doses on their own as there is some potential for lethal toxicity if this drug is not used appropriately.

The high doses of ivermectin used in the treatment of demodicosis are not compatible with the commonly used flea product spinosad (Comfortis®). The combination of spinosad and high doses of ivermectin will increase the likelihood of ivermectin neurologic side effects. While flea control is very important during the treatment of demodectic mange, a different product should be used.

For more information on Ivermectin, click here.

SOMETHING ELSE YOUR VETERINARIAN MIGHT TRY:
           MOXIDECTIN (ADVANTAGE MULTI®)

Moxidectin is another ivermectin derivative that could be used in the treatment of demodicosis (though probably not in ivermectin sensitive animals). In Advantage Multi, moxidectin is administered topically as a dewormer and heartworm preventive to provide broad spectrum parasite control in combination with imidocloprid for flea protection. Moxidectin has activity against demodex mites and is often effective if used weekly in the treatment of demodectic mange.

TRADITIONAL TREATMENT -- AMITRAZ (MITABAN) DIPS

MitabanUnless the animal is largely bald or has a short coat, complete clipping will be required for maximal contact with the dip.

Dip should be preceded by a benzoyl peroxide bath to help clear up skin infections and open the hair follicles so the dip can penetrate to the mites. Shampoo must sit on the pet at least 10 minutes before rinsing. CAUTION: this type of shampoo can stain jewelry and clothing.

Dip is applied by sponge. Gloves should be worn while applying dip. The dip dries on the dog's fur and should not be rinsed off. The dog should not get wet between dips.

Dipping occasionally yields mild sedation as a side effect. Very small dogs may become highly sedated and require an antidote but this is unusual. For your convenience, dipping and bathing may be performed at the hospital thus allowing for veterinary supervision in the event of side effects.

Dipping/bathing is recommended every two weeks according to the FDA approved label on the bottle of dip. Most universities are finding that the cure rate jumps from 25% to 80% when dip is used at double strength and applied weekly. No toxic effects have been seen using the dip in this way and this is our current recommendation when opting for dips except in very small dogs and puppies.

Dipping is a fair alternative for ivermectin in collie breeds and in ivermectin sensitive individuals.

AMITRAZ DIPPING SHOULD NOT BE USED IN TOY BREEDS
OR IN YOUNG (UNDER 4 MONTHS OF AGE) PUPPIES.

NOTE: Amitraz is a drug of the monoamine oxidase inhibitor class. People who are taking selected serotonin reuptake inhibitors (such as fluoxetine) could have a bad reaction to the use of amitraz if they administer dips to pets. Similarly, pets on SSRI's may have reactions to amitraz. Human diabetics should also avoid administering amitraz dips as amitraz may interfere with glucose regulation; diabetic pets may have trouble as well.

SOMETHING ELSE YOUR VETERINARIAN MIGHT TRY -- INTERCEPTOR®

Interceptor greenInterceptor (active ingredient: Milbemycin oxime) is normally marketed as a monthly heartworm preventive; when it is used on a daily basis, it is effective against generalized demodicosis. This discovery was welcomed by the veterinary profession as finally demodicosis could be treated without labor intensive dipping or concern about ivermectin sensitivity. The downside to this treatment is expense as Interceptor is typically sold in 6 dose packages and it is not uncommon for several months of treatment to be needed. Sometimes it is possible to obtain discounted product that is short-dated (meaning it will expire before six months have passed). This product cannot be sold for heartworm prevention if it will expire before it is used up but for daily use against Demodex mites it would be fine and used well before its expiration date.

INTERCEPTOR MAY BE USED IN ANY PATIENT SAFELY;
THE ONLY DOWNSIDE IS EXPENSE.

A FEW NOTES ABOUT PROMERIS®

Promeris® is/was a prescription topical flea and tick product also labeled for the control of demodicosis. Its anti-tick active ingredient is amitraz (the same active ingredient in Mitaban® dip described above). The product is typically used every 2-4 weeks to treat demodicosis and has the advantage of being safe for the collie-type breeds (and other individuals with ivermectin sensitivity). Promeris was withdrawn from the market by Pfizer in 2011 because of immune-mediated reactions emerging with regular use for flea and tick control. Still, some product may still be around and in use so we mention it here.

PROGNOSIS

The younger the dog, the better the chance of cure. Most dogs under one year and a half years of age, recover completely from generalized demodicosis. In many cases of adult-onset demodicosis, the disease is controlled with treatment but cure is not always possible. Some cases can never be controlled.

Treatment, no matter which option is chosen, should be accompanied by skin scrapes every 2 weeks. In this way the effectiveness of treatment is assessed and modifications can be made. After two consecutive scrapes are negative, treatment is discontinued but a final scrape should be performed after one month off therapy. The reason for the final scrape is to be sure the mites are not coming back (which they can do if every single mite on the dog is not eradicated).

RELAPSE?

When relapse occurs it is often because the dog appeared to be normal and the owner did not return for the appropriate re-scrapings. Relapse is always a possibility with generalized demodicosis as there is no easy way to confirm that every mite has been killed but most dogs that relapse do so within a 6-12 month period from the time they appear to have achieved cure.

SARCOPTIC MANGE IS A COMPLETELY DIFFERENT DISEASE.

Click here for information on Sarcoptic mange.

no motor oil smallWE WISH IT WASN’T NECESSARY TO ADD THIS

In older times, some 30 years ago, dipping dogs with demodectic mange in motor oil was a popular home remedy. Skin exposure to motor oil can cause rashes and skin destruction in severe cases. The hydrocarbons can be absorbed through the skin and cause a dangerous drop in blood pressure. If motor oil is licked off the coat, resultant vomiting can lead to aspiration of motor oil into the lungs and pneumonia. Kidney and liver damage can result from motor oil dipping.

PLEASE: DO NOT DIP YOUR DOG IN MOTOR OIL!

FOR INFORMATION ON DEMODECTIC MANGE IN THE CAT:

Page last updated: 11/16/2012