Most of us have heard of bronchitis and most of us have probably suffered from it at some point. The bronchi are the larger airways through which air is moved throughout the lungs. The trachea (windpipe) brings air from the throat down into the chest and branches into two “mainstem” bronchi, one for each lung. Each mainstem bronchus branches into smaller bronchi, which eventually become smaller structures called “bronchioles” which in turn branch and eventually terminate on the alveoli, small chambers were oxygen is actually absorbed into our bodies from the air we inhale. Bronchi are basically tubes made of cartilage forming the larger “pipes” in our lungs.
When the bronchi are injured by irritants (cigarette smoke, air pollution, biochemical products of infection etc.), they respond with a healing process which is inherently inflammatory. When the injury becomes ongoing, the inflammatory/healing process also becomes ongoing and the end result involves excessive mucus production in the airways. The mucus obstructs the smaller bronchi which stimulates coughing, which in turn leads to irritation and then to inflammation and then to more mucus. A vicious cycle results.
Once the vicious cycle (of mucus production to coughing to inflammation to mucus) has become entrenched in the patient, it is unlikely to be cured and therapy is geared towards controlling the symptoms.
WHAT MAKES BRONCHITIS CHRONIC?
Bronchitis can be temporary, as in short-term infectious disease such as Kennel Cough, or it can be chronic, which basically means it has been going on for a long time. To fit the definition of “chronic”, the cough must be present daily for at least a couple of months. There are many causes of ongoing cough; bronchitis is certainly not the only one. It is very important to determine whether or not a reversible underlying cause is present. The sound of the cough is not particularly helpful in determining the cause of the cough.
It is important to realize that there are many conditions that make dogs cough chronically including but not limited to:
(Note that asthma is conspicuously missing from this list. Asthma involves recurring episodes of airway inflammation and narrowing rather than the continuous (non-episodic) airway inflammation. Asthma is not a natural clinical entity in the dog though it is certainly a well-described condition in the cat.)
Radiographs of the lungs are crucial in ruling out conditions that have a specific treatment. In bronchitis, mucus in the airways tends to outline the shape of the airways in patterns that look like parallel lines (so-called “tram lines) when looking at an airway’s side view or circles (so-called “doughnuts”) when looking at an airway end on. The airways may be dilated in bronchitis as well, especially if the case is advanced. Other conditions tend to have characteristic radiographic appearances of their own but there is definitely room for ambiguity.
In a perfect world, bronchoscopy can be performed and samples of the airway secretions can be analyzed. In bronchoscopy, a small video camera is inserted down the airway system. The color and character of the airway walls can be examined and a fluid wash can be used to aspirate out samples of secretions. General anesthesia is required for this procedure.
Bronchoscopy and sampling of airway secretion
Alternatively, a tracheal wash can be done to obtain samples using special tubing and fluid washes. In this procedure, only samples are taken and there is no camera involved and no visual inspection of the airways. Sedation is generally needed.
Sedation and anesthesia are not without risk in patients with lung compromise so the benefit of obtaining diagnostic information must be weighed against patient risk. Often invasive procedures are skipped and trial courses of medication are used.
TRIAL COURSES OF MEDICATION
Different individuals respond to different medications and in bronchitis there are several options to choose from and even combine.
Cough Suppressants The cough itself is involved in the vicious cycle of irritation described above. Suppression of the cough reflex through medication may be helpful in establishing patient comfort. On the other hand, we want our patient to be able to clear the mucus from the inflamed airways if there is an excess of mucus present. Common medications used are hydrocodone and butorphanol. Over-the-counter human products are often ineffective and may be combined with harmful additional medications such as decongestants or pain relievers.
Never medicate your pet without checking with your veterinarian first about what product to use and how to dose it.
Airway Dilators Although, airways technically do not constrict in chronic bronchitis, it may be helpful to relax them allowing air to pass through bronchi that had previously been so small as to be occluded by mucus. Common medications include: albuterol, terbutaline, and theophylline.
Antihistamines Histamine is an important biochemical mediator of inflammation in people and a proliferation of antihistamines are available over-the-counter because of this. Unfortunately, histamine is not a very important mediator of inflammation in dogs; however, antihistamines still have some ability to dry up airway secretions. It is important to note that after long-term use of an antihistamine, tolerance develops and it becomes necessary to switch to a new antihistamine eventually.
Human antihistamines are often combined with other medications, such as decongestants, which can be harmful. Never medicate your pet on your own. Check with your vet about what to use and how to use it.
Corticosteroids Corticosteroids such as prednisone relieve inflammation and cut secretions like no other medication can. Typically a short course is used to control symptoms initially followed by a lower dose maintenance course. This helps dry up the mucus in the airways and stop the cough-irritation vicious cycle. The problem is that oral steroids have side effects potential with long term use. Further, because they are suppressive to the inflammatory process it is especially important to have ruled out infectious causes of coughing which might be made worse with steroid use.
Aerodawg inhaler device
As an alternative to oral steroids, inhaled steroids can be used as is done with human asthmatics. A special facemask is used and a “spacer” connects the mask to the metered dose inhaler. A couple of puffs from the inhaler doses the dog with inhaled steroids and it is possible to avoid the systemic side effects associated with oral steroids. Dogs typically need to use inhalers at least twice a day to control the symptoms of bronchitis. Airway dilators can also be given via inhalation in the same way as steroids.
Antibiotics? Chronic bronchitis is not an infectious disease but all the inflammation and mucus in the lung certainly compromises the patient’s normal resistance to infection and ability to clear inhaled bacteria. Sometimes antibiotics are a helpful temporary addition to the therapies listed above.
Typical medical nebulizer. Obviously a dog will not hold the mouthpiece in its mouth. The mouthpiece can be held up to the dog’s face or the apparatus can be hooked up to a crate with the dog inside.
Nebulization and Coupage It is important for the patient with bronchitis to cough up inflammatory secretions so long as coughing does not become excessive and perpetuate the inflammation. It is not easy to draw the line as to when cough is helpful and when it is excessive; only experience will tell. In patients for whom coughing is best encouraged, it may be useful to moisten secretions with a vaporizer or even a nebulizer (the difference in these pieces of equipment being the size of the water droplet they generate). Inhalation of water vapor a couple of times daily will help keep secretions moist.
Coupage is a form of respiratory physical therapy which allows for moistened secretions to be moved into more central airways so they can be coughed up. See video below for details.
Obesity Management Pressure on the chest from body fat hampers the patient’s ability to take a deep breath. Many patients with chronic coughs do not require medication after excess weight has been lost simply because the chest can then expand properly.
Chronic bronchitis represents an ongoing airway change that generally cannot be cured; however, symptoms are manageable for most patients. Discuss the options for therapy with your veterinarian, expect some trial and error to be necessary, and it is likely the outcome will be a system that keeps your pet comfortable.