GLUCOSAMINE / CHONDROITIN SULFATE
(for veterinary information only)
BRAND NAMES: COSEQUIN, DASUQUIN, GLYCOFLEX, FLEXADIN, CANIFLEX, SYNOVI, AND NUMEROUS (NEARLY UNCOUNTABLE) OTHERS
HISTORY AND BACKGROUND
Degenerative joint disease, commonly called “arthritis,” is a painful condition frequently treated with pain-relievers, anti-inflammatory medications, supplements, physical therapy and even weight loss. It has been of interest to seek medications which might actually strengthen damaged cartilage and potentially complement these other therapies. Glucosamine and chondroitin sulfates represent solutions to this problem.
In a normal joint, cartilage breakdown is balanced by cartilage production. In the diseased joint, there is more breakdown than production. Glucosamine & chondroitin sulfates are components of cartilage and the theory is that by taking these precursors orally, one's body can use them to repair and rebuild cartilage where it is damaged. This has actually borne out and studies show that cartilage "building blocks" taken orally are indeed utilized in cartilage repair. The cartilage cells of the joint are able to manufacture their own glucosamine but this ability appears to decrease with disease and with age and may not be able to keep up with the need for glucosamine when there is an increased demand. It has further been suggested that these substances may have anti-inflammatory properites of their own and/or may act by stimulating the synthesis of joint lubricants and collagen within the damaged joint, thus contributing further therapeutic benefit.
In humans, glucosamine supplements can adversely impact asthma symptoms. This appears to be a human situation but it may be prudent to avoid it in patients with airway constriction.
Upset stomach has been reported in small animals as a rare side effect.
INTERACTIONS WITH OTHER DRUGS
None have ever been reported.
Nutriceuticals are not regulated by the FDA as they are not considered "drugs." This means that they can be sold without scientific proof of efficacy and without mandatory testing to determine the optimal dosage. It is also not required that the manufacturer demonstrate that the pills actually contain the amount of active ingredient that the label claims they do.There are numerous anecdotal reports of these medications helping numerous individuals but one should keep in mind that scientific investigation is continuing. At present, there have been numerous studies in a wide variety of scientific quality. Some experts feel there is inadequate hard evidence while others feel there is more than enough evidence to justify their use particularly given that they have very little potential for adverse effects. To make the best choice in a joint supplement product, it is best to go by your veterinarian's recommendation. For best bioavailability, use a product labeled for the species in which you plan to use it.
Be sure to store the product away from moisture and away from light.
Page last updated: 5/18/2018