Mar Vista Animal Medical Center

3850 Grand View Blvd.
Los Angeles, CA 90066

(310)391-6741

www.marvistavet.com

DEXMEDETOMIDINE

(for veterinary information only)

BRAND NAMES: SILEO, DEXDOMITOR

 

AVAILABLE AS: ORAL GEL, INJECTABLE

 

BACKGROUND

Noise aversion can be a serious problem for a pet dog. Not only is the associated panic unpleasant but the frightened animal can become destructive or even dangerous. It is not unusual for a terrified dog to break down doors or even windows in an escape attempt. The animal may bite or potentially escape from a yard or pen and become lost. The pet is experiencing a panic disorder and likely could do with pharmacological assistance in times when loud noises are expected.

Past remedies have involved acepromazine, which induces drowsiness and impairs mobility without a lot of anxiety reduction. Benzodiazepine tranquilizers,  such as alprazolam, have been felt to be superior for relief of panic. In 2016, an oral form of dexmedetomidine became available for use in dogs with noise aversion.

Dexdomitor has been widely used in veterinary anesthesia for decades because it is effective, reversible, and provides good analgesia. The oral gel released for noise phobia uses a low dose of this medication so as to relieve anxiety without inducing sedation.

HOW THIS MEDICATION IS USED

Dexmedetomidine oral gel is administered in the cheek pouch of the dog, rather than into the mouth. The person administering the medication should wear gloves when handling the syringe and medication is ideally given 30-60 minutes before the noise is expected. Additional doses may be given if necessary but it is important to wait at least 2 hours between doses. Up to 5 doses can be given per noise event.

The syringe applicator comes with a dial up dosing handle. It is important to know where to dial your pet's dose on the handle.

If dexmedetomidine is delivered in the mouth and not the cheek pouch, it will not absorb properly and will not be effective. If this happens, wait two hours before re-dosing.

Do not feed for 2 hours after administration.

 

INTERACTIONS WITH OTHER DRUGS

Use of this product with other tranquilizers or anti-anxiety medications can increase potential for side effects. Be sure your veterinarian is aware of all other medications your pet uses.

SIDE EFFECTS

The dog's gums may appear pale shortly after administration of dexmedetomidine gel. This is not of significance and can be considered a normal reaction if it occurs.

Dexmedetomidine has potential to drop blood pressure and drop heart rate. Neither of these effects should be significant in normal patients.

Dexmedetomidine is an anesthetic drug but should not cause sedation at these doses. That said, sedation might be seen in a sensitive animal.

 

CONCERNS AND CAUTIONS

Dexmedetomidine gel is for healthy dogs. It should not be used in dogs with heart disease, kidney disease, respiratory compromise, exhaustion, or heat stress.

The dosing syringe is good for 2 weeks after it is opened and may be used again in this time frame.

Dogs with more deep-seated or long term anxiety (rather than just fear of loud-noises that occur only periodically) will need a different treatment plan. Dexmedetomidine is for dogs who suffer from noise aversion but not from general anxiety states.

Safety of this product has not been evaluated in puppies under 16 weeks of age nor in pregnant or nursing female dogs.

The manufacturer recommends that pregnant women not handle this product.

Page posted: 8/27/2016
Page last updated: 6/28/2017