COMMON LYMPHOMA CHEMOTHERAPY MEDICATIONS

The word "chemotherapy" conjures up images of unpleasant toxicity but in reality, "chemotherapy" just refers to the use of medications (as opposed to radiation or surgery) in the treatment of cancer. Unpleasant side effects are actually unusual for pets, not just from species differences but because disease-free duration goals are different when normal lifespans are shorter. Protocols can involve combinations of different medications. (Acronyms for these drugs form the name of the protocol such as: COP, CHOP, MOPP). Protocols can also be "single agent" meaning only one drug is used. In general, the chance of achieving remission is good no matter which protocol but the duration of remission will depend on the type of lymphoma and which protocol is selected. There is some controversy as to whether chemotherapy protocols should be used indefinitely or for a finite period of time.

Eventually, it can be expected that remission will be lost and a "rescue" protocol will be needed to achieve a second remission. The second remission is generally more difficult to achieve and will not last as long as the first remission. The medications selected for rescue will need to be different from those used in the original protocol because the tumor can be assumed to be resistant to the drugs it has already been exposed to.

The following list includes medications that are commonly used in the treatment of lymphoma in dogs and cats. Your veterinarian or veterinary oncologist will likely be suggesting a protocol involving one or more of these. Use the links below to obtain more information.

PREDNISONE / PREDNISOLONE

CYCLOPHOSPHAMIDE (CYTOXAN)

ADRIAMYCIN / DOXORUBICIN

METHOTREXATE

CHLORAMBUCIL (LEUKERAN)

LOMUSTINE (CCNU)

VINCRISTINE (ONCOVIN)

L-ASPARAGINASE (ELSPAR)

PROCARBAZINE

DACARBAZINE

RABACFOSADINE (TANOVEA-CA1)

VERDINEXOR (LAVERDIA-CA1) (conditionally approved for treatment)

Page posted: 5/27/2023