Mar Vista Animal Medical Center

3850 Grand View Blvd.
Los Angeles, CA 90066

(310)391-6741

www.marvistavet.com

AFOXOLANER

BRAND NAME: NEXGARD

 

AVAILABLE IN
11.3 MG, 28.3 MG, 68 MG, 136 MG
CHEWABLE TABLETS

     

BACKGROUND

In older times, flea control was a very labor-intensive process involving sprays, dips, foggers, yard sprays, powders and more. As technology progressed, products became safer and more convenient culminating in a whole “next generation” of products starting with Program® in 1995, and Advantage® and Frontline® not long after. For the first time, flea control could be performed once a month in the simple form of a chewable tablet or smear of topical oil. These products represented a revolution in flea control but the revolution did not stop there. Today parasite control has proliferated into dozens of products controlling different combinations of organisms and with many administration options.

HOW THIS MEDICATION IS USED

Afloxolaner was released by Merial Animal Health in 2014 as a beef-flavored chewable prescription medication called "Nexgard®."  A related product called "Nexgard Spectra®" is available in Europe. Nexgard Spectra combines afoxolaner and milbemycin, an anti-worm medicine, so as to provide nearly total parasite protection in one product but this version of Nexgard is not presently available in the U.S. A valid patient-doctor relationship is required to obtain a prescription for afoxolaner. Nexgard kills fleas and ticks only and has no activity against intestinal worms or heartworm. There are four ticks of concern in the U.S. (see our tick product comparison chart for more details) and afoxolaner will kill all of them. As for fleas, afloxolaner kills fleas before they are able to lay eggs so that a flea sterilizer is not necessary in the tablet.

Afoxolaner lasts one month and can be used in puppies/dogs 8 weeks of age and older so long as they weigh at least 4 lbs. It should not be used in cats.

Afoxolaner can be given either with or without food.

SIDE EFFECTS

The possible side effects reported include nausea/vomiting (4% of dogs), diarrhea (3% of dogs) dandruffy coat (3% of dogs), lethargy (less than 2% of dogs) and appetite loss (less than 2% of dogs). Most dogs that exhibited one of these side effects only exhibited them after the first dose and not with subsequent doses.

If a dog vomits within 2 hours of administration of a Nexgard tablet, a new tablet should be given. If vomiting occurs after 2 hours, re-dosing is not necessary.

 

INTERACTIONS WITH OTHER DRUGS

There are no known drug interactions with afoxolaner.

 

CONCERNS AND CAUTIONS

Afoxolaner has not been evaluated in pregnant or nursing animals so it is recommended not to use afoxolaner in this situation.

Afoxolaner kills fleas by causing an over-stimulation of the insect nervous system. This leads fleas to be extra active just before they die; this increase in activity can lead the fleas to be more visible.

The manufacturer recommends caution in dogs with known seizure disorders. This means that it is not clear whether or not afoxolaner has the potential to promote seizures in dogs already predisposed to having seizures.

For more information on afoxolaner visit:

www.nexgardfordogs.com

Page posted 9/17/2016