Confused about flea protection? This FAQ compares all the currently available flea control products to assist you in determining which is right for your situation. These products are available at licensed veterinary hospitals. If you would like to know why we haven’t included over the counter products (as would be sold in a grocery or pet supply store), click here. Because there are 14 different products compared in 16 different categories, we have split up the information into 4 separate tables

Table 1:	Flea killing ingredient; Flea sterilizing or additional ingredients; For dogs or cats; Youngest age or size approved for use; Waterproof or water resistant
Table 2:	Approved for pregnancy or lactation (nursing); How long until maximum effect against fleas is reached; Other parasites killed, controlled or repelled; How often applied or administered
Table 3:	Oral or Topical, Prescription drug, non-prescription drug or insecticide; LD50 (lethal dose to 50% of the population)
Table 4:	Year first made available in U.S.; Manufacturer, Manufacturer’s website; Additional cautions

TABLE 1	Flea Killing Ingredient	Flea Sterilizing or Additional Ingredients	For Dogs or Cats	Youngest Age or Size Approved For Use	Waterproof or Water Resistant?
Comfortis, AcuGuard*	Spinosad	none	Dog	14 weeks; at least 5 lbs	Waterproof
Trifexis	Spinosad	Milbemycin (for add’l parasites)	Dogs	8 weeks; at least 5 lbs	Waterproof
Assurity	Spinetoram	none	Cats	8 weeks	Water Resistant
Vectra 3D, SimpleGuard 3*, FirstShield Trio*	Dinotefuran & Permethrin	Pyriproxifen (flea sterilizer)	Dog	7 weeks; at least 2.5 lbs	Water Resistant
Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*	Dinotefuran	Pyriproxifen (flea sterilizer)	Cats	8 weeks	Water Resistant
Revolution	Selamectin	none	Dog or Cat	6 weeks puppies 8 weeks kittens	Waterproof
Advantage II	Imidacloprid	Pyriproxifen (flea sterilizer)	Dog or Cat	7 weeks puppies 8 weeks kittens	Waterproof
K9Advantix II	Imidacloprid & Permethrin	Pyriproxifen (flea sterilizer)	Dog	7 weeks	Waterproof
Advantage Multi also called Advocate	Imidacloprid	Moxidectin (for additional parasites)	Dog or Cat	7 weeks puppies 9 weeks kittens	Waterproof
Frontline Fiproguard, PetArmor, EasySpot (cats) Parastar (dogs)	Fipronil	none	Dog or Cat	8 weeks	Waterproof
Frontline Plus, Fiproguard Plus, PetArmor Plus	Fipronil	Methoprene (flea sterilizer)	Dog or Cat	8 weeks	Waterproof
Program	none	Lufenuron (flea sterilizer)	Dog or Cat	4 weeks	Waterproof
Sentinel	none	Lufenuron (flea sterilizer) & Milbemycin (for add’l parasites)	Dog	4 weeks; at least 2 lbs	Waterproof
Capstar	Nitenpyram	none	Dog or Cat	4 weeks; at least 2 lbs	Waterproof

TABLE 2	Approved for Pregnancy and Lactation (nursing)	How Long Until Maximum Effect Against Fleas Is Reached?	Other Parasites Killed, Controlled or Repelled	How Often Applied or Administered?
Comfortis, AcuGuard*	Manufacturer recommends against use but not specifically labeled against	100% Fleas Dead in 4 Hours	none	Monthly
Trifexis	Manufacturer recommends against use but not specifically labeled against	100% Fleas Dead in 4 Hours	Hookworms, Roundworms, Whipworms & Heartworm	Monthly
Assurity	Manufacturer recommends consulting with veterinarian first	98 - 100% Fleas Dead in 12 Hours	none	Monthly
Vectra 3D, SimpleGuard 3*, FirstShield Trio*	No	96% of Fleas Dead in 6 Hours	Kills Ticks; Repels Flies and Mosquitos	Monthly
Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*	No	98% of Fleas Dead in 6 Hours	none	Monthly
Revolution	Yes	42 Hours to Zero Fleas	Dogs: Ticks, Ear Mites, Sarcoptic Mange Mites & Heartworm Larvae Cats: Hookworms, Roundworms, Ear Mites & Heartworm Larvae	Monthly
Advantage II	Manufacturer recommends consulting with veterinarian first	98% of Pre-Existing Fleas Dead in 12 Hours; Then New Fleas in 2 Hours	none	Monthly
K9Advantix II	No	98% of Fleas Dead in 12 Hours	Kills Ticks; Repels Flies and Mosquitos	Monthly
Advantage Multi also called Advocate	No	98% of Fleas Dead in 12 Hours	Dogs: Whipworms, Hookworms, Roundworms & Heartworm Cats: Hookworms, Roundworms, Ear Mites & Heartworm	Monthly
Frontline, Fiproguard, PetArmor EasySpot (cats) Parastar (dogs)	Topspot Yes; Spray No	24 Hrs to Translocate, then 4-18 Hours to Kill Fleas	Kills Ticks & Lice	Monthly
Frontline Plus, Fiproguard Plus, PetArmor Plus	Yes	24 Hrs to Translocate, then 4-18 Hrs to Kill Fleas and 24-48 Hours to Kill Ticks	Kills Ticks & Lice	Monthly
Program	Yes	Peak activity at 6 Hours	none	Monthly for oral; Every 6 Months for Injectable
Sentinel	Individual ingredients Yes, but combination not approved	Peak activity at 6 Hours	Hookworms, Roundworms, Whipworms & Heartworm	Monthly
Capstar	Yes	Maximum Effect in 4 Hours	none	As Needed or Daily (no lasting activity)

TABLE 3	Oral or Topical?	Prescription Drug, Non-Prescription Drug or Insectcide	Lethal Dose to 50% of the Population (the higher the number, the safer the product) [What is LD50?]
Comfortis, AcuGuard*	Oral (Chewable)	Prescription Drug	>3,000 mg/kg in rats; >2.000 mg/kg in rabbits (translates to over 30 times recommended dose)
Trifexis	Oral (Chewable)	Prescription Drug	Spinosad: >3,000 mg/kg in rats; >2.000 mg/kg in rabbits Milbemycin LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
Assurity	Topical	Insecticide	Dermal and Oral LD50 in rats > 5,000 mg/kg
Vectra 3D, SimpleGuard 3*, FirstShield Trio*	Topical	Insecticide	>2,400 mg/kg in rats for Dinotefuran, >4,000 mg/kg in rats for topical Permethrin
Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*	Topical	Insecticide	>2,400 mg/kg in rats for Dinotefuran
Revolution	Applied Topically, but rapidly absorbed through skin	Prescription Drug	>1,600 mg/kg in rats
Advantage II	Topical	Insecticide	Dermal Dose: >5,000 mg/kg in rats Orally: 450 mg/kg in rats
K9Advantix II	Topical	Insecticide	Imidacloprid Dermal Dose: >5,000 mg/kg in rats Imidacloprid Orally: 450 mg/kg in rats >4,000 mg/kg in rats for Permethrin
Advantage Multi also called Advocate	Topical	Prescription Drug	Imidacloprid Dermal Dose: >5,000 mg/kg in rats Imidacloprid Orally: 450 mg/kg in rats >2,000 mg/kg in rabbits for Moxidectin
Frontline, Fiproguard, PetArmor EasySpot (cats) Parastar (dogs)	Topical Topspot or Spray	Insecticide	Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats
Frontline Plus, Fiproguard Plus, PetArmor Plus	Topical	Insecticide	Fipronil Dermal Dose: >5,000 mg/kg in rats Fipronil Orally: 750 mg/kg in rats Methoprene Orally: >34,600 in rats (virtually non-toxic)
Program	Oral; or Injectable for Cats only	Over the Counter Drug	Orally: > 2,000 mg/kg in rats
Sentinel	Oral	Prescription Drug	Lufenuron Orally: > 2,000 mg/kg in rats Milbemycin LD50 information unavailable Symptoms of tremors and incoordination result at 19 times recommended dose
Capstar	Oral	Over the Counter Drug	Orally: 1,575 mg/kg in rats

TABLE 4	Year First Made Available in U.S.	Manufacturer	Manufacturer Website	Additional Cautions
Comfortis, AcuGuard*	2007	Elanco	www.comfortis4dogs.com (AcuGuard is a private label*)	Should not be used in dogs with known seizure disorders
Trifexis	2011	Elanco	www.trifexis.com	Puppies less than 14 weeks of age may experience a higher rate of vomiting
Assurity	2011	Elanco	www.assurity4cats.com	none
Vectra 3D, SimpleGuard 3*, FirstShield Trio*	2007	Summit	www.summitvetpharm.com (SimpleGuard 3 and FirstShield Trio are private labels*)	none
Vectra for Cats, SimpleGuard for Cats*, FirstShield for Cats*	2008	Summit	www.summitvetpharm.com (SimpleGuard for Cats and FirstShield for Cats are private labels*)	none
Revolution	2000	Pfizer	www.revolutionpet.com	Pets should test negative for Heartworm before use
Advantage II	1996	Bayer	http://advantage.petparents.com	none
K9Advantix II	2003	Bayer	http://k9advantix.petparents.com	Do not use in cats (cats are sensitive to Permethrin)
Advantage Multi also called Advocate	2007	Bayer	http://advantagemulti.petparents.com	Pets should test negative for Heartworm before use
Frontline, Fiproguard, PetArmor EasySpot (cats) Parastar (dogs)	1996 (Frontline) 2011 (all others)	Merial Sentry FidoPharm	www.frontline.com www.sentrypetcare.com www.petarmor.com www.easyspotpet.com www.parastarpet.com	none
Frontline Plus, Fiproguard Plus, PetArmor Plus	2000	Merial Sentry FidoPharm	www.frontline.com www.sentrypetcare.com www.petarmor.com	none
Program	1994	Novartis	www.program.novartis.us	Give with food
Sentinel	1997	Novartis	www.sentinel.novartis.us	Give with food; Pets should test negative for Heartworm before use
Capstar	2000	Novartis	www.capstar.novartis.us	none